Influenza vaccination is associated with reduced severity of community-acquired pneumonia.
Identifieur interne : 000290 ( Main/Exploration ); précédent : 000289; suivant : 000291Influenza vaccination is associated with reduced severity of community-acquired pneumonia.
Auteurs : A. Tessmer [Allemagne] ; T. Welte ; R. Schmidt-Ott ; S. Eberle ; G. Barten ; N. Suttorp ; T. SchabergSource :
- The European respiratory journal [ 1399-3003 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Allemagne, Femelle, Grippe humaine (), Humains, Infections communautaires (mortalité), Infections communautaires (physiopathologie), Mâle, Pneumopathie infectieuse (mortalité), Pneumopathie infectieuse (physiopathologie), Résultat thérapeutique, Saisons, Sujet âgé, Vaccination, Vaccins antigrippaux (usage thérapeutique), Études de cohortes.
- MESH :
- mortalité : Infections communautaires, Pneumopathie infectieuse.
- physiopathologie : Infections communautaires, Pneumopathie infectieuse.
- usage thérapeutique : Vaccins antigrippaux.
- Adulte d'âge moyen, Allemagne, Femelle, Grippe humaine, Humains, Mâle, Résultat thérapeutique, Saisons, Sujet âgé, Vaccination, Études de cohortes.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Aged, Cohort Studies, Community-Acquired Infections (mortality), Community-Acquired Infections (physiopathology), Female, Germany, Humans, Influenza Vaccines (therapeutic use), Influenza, Human (complications), Male, Middle Aged, Pneumonia (mortality), Pneumonia (physiopathology), Seasons, Treatment Outcome, Vaccination.
- MESH :
- chemical , therapeutic use : Influenza Vaccines.
- geographic : Germany.
- complications : Influenza, Human.
- mortality : Community-Acquired Infections, Pneumonia.
- physiopathology : Community-Acquired Infections, Pneumonia.
- Aged, Cohort Studies, Female, Humans, Male, Middle Aged, Seasons, Treatment Outcome, Vaccination.
Abstract
Pneumonia is an important cause of influenza-associated morbidity and mortality. Influenza vaccination has been shown to reduce morbidity and mortality during influenza seasons. Protection from severe pneumonia may contribute to the beneficial effect of influenza vaccination. Therefore, we investigated the impact of prior influenza vaccination on disease severity and mortality in patients with community-acquired pneumonia (CAP). Analysis from an observational, multicentre cohort study initiated by the German competence network for CAP was performed. Patients were analysed separately as an influenza season and off-season cohort. Associations between vaccination status and outcome parameters were evaluated by multivariate analyses. In the season cohort (2,368 patients) CAP in vaccinated patients was significantly less severe according to most analysed parameters (CURB index ≥ 1: OR 0.76, 95% CI 0.60-0.98; procalcitonin ≥ 2.0 ng·mL(-1): OR 0.53, 95% CI 0.35-0.81; procalcitonin ≥ 0.5 ng·mL(-1): OR 0.71, 95% CI 0.51-0.99) and these patients showed a significantly better overall survival within the 6-month follow-up period (HR 0.63, 95% CI 0.45-0.89). Within the off-season cohort (2,632 patients) there was no significant influence of vaccination status on CAP severity or disease outcome. In conclusion, prior influenza vaccination was associated with less severe clinical course and improved overall long-term survival in patients with CAP during influenza seasons.
DOI: 10.1183/09031936.00133510
PubMed: 21148226
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza vaccination is associated with reduced severity of community-acquired pneumonia.</title><author><name sortKey="Tessmer, A" sort="Tessmer, A" uniqKey="Tessmer A" first="A" last="Tessmer">A. Tessmer</name><affiliation wicri:level="3"><nlm:affiliation>Dept of Infectious Disease and Respiratory Medicine, Charité-University Medicine, Campus Virchow Klinikum and Campus Mitte, Augustenburger Platz 1, 13353 Berlin, Germany. antje.tessmer@charite.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept of Infectious Disease and Respiratory Medicine, Charité-University Medicine, Campus Virchow Klinikum and Campus Mitte, Augustenburger Platz 1, 13353 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Welte, T" sort="Welte, T" uniqKey="Welte T" first="T" last="Welte">T. Welte</name></author><author><name sortKey="Schmidt Ott, R" sort="Schmidt Ott, R" uniqKey="Schmidt Ott R" first="R" last="Schmidt-Ott">R. Schmidt-Ott</name></author><author><name sortKey="Eberle, S" sort="Eberle, S" uniqKey="Eberle S" first="S" last="Eberle">S. Eberle</name></author><author><name sortKey="Barten, G" sort="Barten, G" uniqKey="Barten G" first="G" last="Barten">G. Barten</name></author><author><name sortKey="Suttorp, N" sort="Suttorp, N" uniqKey="Suttorp N" first="N" last="Suttorp">N. Suttorp</name></author><author><name sortKey="Schaberg, T" sort="Schaberg, T" uniqKey="Schaberg T" first="T" last="Schaberg">T. Schaberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21148226</idno><idno type="pmid">21148226</idno><idno type="doi">10.1183/09031936.00133510</idno><idno type="wicri:Area/Main/Corpus">000312</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000312</idno><idno type="wicri:Area/Main/Curation">000312</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000312</idno><idno type="wicri:Area/Main/Exploration">000312</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Influenza vaccination is associated with reduced severity of community-acquired pneumonia.</title><author><name sortKey="Tessmer, A" sort="Tessmer, A" uniqKey="Tessmer A" first="A" last="Tessmer">A. Tessmer</name><affiliation wicri:level="3"><nlm:affiliation>Dept of Infectious Disease and Respiratory Medicine, Charité-University Medicine, Campus Virchow Klinikum and Campus Mitte, Augustenburger Platz 1, 13353 Berlin, Germany. antje.tessmer@charite.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept of Infectious Disease and Respiratory Medicine, Charité-University Medicine, Campus Virchow Klinikum and Campus Mitte, Augustenburger Platz 1, 13353 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Welte, T" sort="Welte, T" uniqKey="Welte T" first="T" last="Welte">T. Welte</name></author><author><name sortKey="Schmidt Ott, R" sort="Schmidt Ott, R" uniqKey="Schmidt Ott R" first="R" last="Schmidt-Ott">R. Schmidt-Ott</name></author><author><name sortKey="Eberle, S" sort="Eberle, S" uniqKey="Eberle S" first="S" last="Eberle">S. Eberle</name></author><author><name sortKey="Barten, G" sort="Barten, G" uniqKey="Barten G" first="G" last="Barten">G. Barten</name></author><author><name sortKey="Suttorp, N" sort="Suttorp, N" uniqKey="Suttorp N" first="N" last="Suttorp">N. Suttorp</name></author><author><name sortKey="Schaberg, T" sort="Schaberg, T" uniqKey="Schaberg T" first="T" last="Schaberg">T. Schaberg</name></author></analytic><series><title level="j">The European respiratory journal</title><idno type="eISSN">1399-3003</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cohort Studies</term><term>Community-Acquired Infections (mortality)</term><term>Community-Acquired Infections (physiopathology)</term><term>Female</term><term>Germany</term><term>Humans</term><term>Influenza Vaccines (therapeutic use)</term><term>Influenza, Human (complications)</term><term>Male</term><term>Middle Aged</term><term>Pneumonia (mortality)</term><term>Pneumonia (physiopathology)</term><term>Seasons</term><term>Treatment Outcome</term><term>Vaccination</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Allemagne</term><term>Femelle</term><term>Grippe humaine ()</term><term>Humains</term><term>Infections communautaires (mortalité)</term><term>Infections communautaires (physiopathologie)</term><term>Mâle</term><term>Pneumopathie infectieuse (mortalité)</term><term>Pneumopathie infectieuse (physiopathologie)</term><term>Résultat thérapeutique</term><term>Saisons</term><term>Sujet âgé</term><term>Vaccination</term><term>Vaccins antigrippaux (usage thérapeutique)</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Community-Acquired Infections</term><term>Pneumonia</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections communautaires</term><term>Pneumopathie infectieuse</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections communautaires</term><term>Pneumopathie infectieuse</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Community-Acquired Infections</term><term>Pneumonia</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Seasons</term><term>Treatment Outcome</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Allemagne</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Saisons</term><term>Sujet âgé</term><term>Vaccination</term><term>Études de cohortes</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pneumonia is an important cause of influenza-associated morbidity and mortality. Influenza vaccination has been shown to reduce morbidity and mortality during influenza seasons. Protection from severe pneumonia may contribute to the beneficial effect of influenza vaccination. Therefore, we investigated the impact of prior influenza vaccination on disease severity and mortality in patients with community-acquired pneumonia (CAP). Analysis from an observational, multicentre cohort study initiated by the German competence network for CAP was performed. Patients were analysed separately as an influenza season and off-season cohort. Associations between vaccination status and outcome parameters were evaluated by multivariate analyses. In the season cohort (2,368 patients) CAP in vaccinated patients was significantly less severe according to most analysed parameters (CURB index ≥ 1: OR 0.76, 95% CI 0.60-0.98; procalcitonin ≥ 2.0 ng·mL(-1): OR 0.53, 95% CI 0.35-0.81; procalcitonin ≥ 0.5 ng·mL(-1): OR 0.71, 95% CI 0.51-0.99) and these patients showed a significantly better overall survival within the 6-month follow-up period (HR 0.63, 95% CI 0.45-0.89). Within the off-season cohort (2,632 patients) there was no significant influence of vaccination status on CAP severity or disease outcome. In conclusion, prior influenza vaccination was associated with less severe clinical course and improved overall long-term survival in patients with CAP during influenza seasons.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21148226</PMID><DateCompleted><Year>2012</Year><Month>01</Month><Day>23</Day></DateCompleted><DateRevised><Year>2013</Year><Month>05</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1399-3003</ISSN><JournalIssue CitedMedium="Internet"><Volume>38</Volume><Issue>1</Issue><PubDate><Year>2011</Year><Month>Jul</Month></PubDate></JournalIssue><Title>The European respiratory journal</Title><ISOAbbreviation>Eur. Respir. J.</ISOAbbreviation></Journal><ArticleTitle>Influenza vaccination is associated with reduced severity of community-acquired pneumonia.</ArticleTitle><Pagination><MedlinePgn>147-53</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1183/09031936.00133510</ELocationID><Abstract><AbstractText>Pneumonia is an important cause of influenza-associated morbidity and mortality. Influenza vaccination has been shown to reduce morbidity and mortality during influenza seasons. Protection from severe pneumonia may contribute to the beneficial effect of influenza vaccination. Therefore, we investigated the impact of prior influenza vaccination on disease severity and mortality in patients with community-acquired pneumonia (CAP). Analysis from an observational, multicentre cohort study initiated by the German competence network for CAP was performed. Patients were analysed separately as an influenza season and off-season cohort. Associations between vaccination status and outcome parameters were evaluated by multivariate analyses. In the season cohort (2,368 patients) CAP in vaccinated patients was significantly less severe according to most analysed parameters (CURB index ≥ 1: OR 0.76, 95% CI 0.60-0.98; procalcitonin ≥ 2.0 ng·mL(-1): OR 0.53, 95% CI 0.35-0.81; procalcitonin ≥ 0.5 ng·mL(-1): OR 0.71, 95% CI 0.51-0.99) and these patients showed a significantly better overall survival within the 6-month follow-up period (HR 0.63, 95% CI 0.45-0.89). Within the off-season cohort (2,632 patients) there was no significant influence of vaccination status on CAP severity or disease outcome. In conclusion, prior influenza vaccination was associated with less severe clinical course and improved overall long-term survival in patients with CAP during influenza seasons.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tessmer</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Dept of Infectious Disease and Respiratory Medicine, Charité-University Medicine, Campus Virchow Klinikum and Campus Mitte, Augustenburger Platz 1, 13353 Berlin, Germany. antje.tessmer@charite.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Welte</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Schmidt-Ott</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Eberle</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Barten</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Suttorp</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Schaberg</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><CollectiveName>CAPNETZ study group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>12</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur Respir J</MedlineTA><NlmUniqueID>8803460</NlmUniqueID><ISSNLinking>0903-1936</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017714" MajorTopicYN="N">Community-Acquired Infections</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011014" MajorTopicYN="N">Pneumonia</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21148226</ArticleId><ArticleId IdType="pii">09031936.00133510</ArticleId><ArticleId IdType="doi">10.1183/09031936.00133510</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><noCountry><name sortKey="Barten, G" sort="Barten, G" uniqKey="Barten G" first="G" last="Barten">G. Barten</name><name sortKey="Eberle, S" sort="Eberle, S" uniqKey="Eberle S" first="S" last="Eberle">S. Eberle</name><name sortKey="Schaberg, T" sort="Schaberg, T" uniqKey="Schaberg T" first="T" last="Schaberg">T. Schaberg</name><name sortKey="Schmidt Ott, R" sort="Schmidt Ott, R" uniqKey="Schmidt Ott R" first="R" last="Schmidt-Ott">R. Schmidt-Ott</name><name sortKey="Suttorp, N" sort="Suttorp, N" uniqKey="Suttorp N" first="N" last="Suttorp">N. Suttorp</name><name sortKey="Welte, T" sort="Welte, T" uniqKey="Welte T" first="T" last="Welte">T. Welte</name></noCountry><country name="Allemagne"><region name="Berlin"><name sortKey="Tessmer, A" sort="Tessmer, A" uniqKey="Tessmer A" first="A" last="Tessmer">A. Tessmer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/GrippeAllemagneV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000290 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000290 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= GrippeAllemagneV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:21148226
|texte= Influenza vaccination is associated with reduced severity of community-acquired pneumonia.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21148226" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeAllemagneV3
| This area was generated with Dilib version V0.6.35. |  |